KMID : 1146920200500060583
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Journal of Pharmaceutical Investigation 2020 Volume.50 No. 6 p.583 ~ p.592
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Distribution of ¡°molybdenum disulfide/cobalt ferrite¡± nanocomposite in animal model of breast cancer, following injection via differential infusion flow rates
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Alavijeh Mohammadhossein Shahsavari
Maghsoudpour Adel Khayat Morteza Rad Iman Hatamie Shadie
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Abstract
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Purpose: Aims were to investigate pattern of distribution of ¡°molybdenum disulfide/cobalt ferrite¡± magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor.
Methods: MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors¡¯ outer dimensions, histopathology and qRT-PCR assay techniques.
Results: Neither MoS2/CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 ¥ìg/ml injected by speed rate of 10 ¥ìl/min to the tumor in the presence of AMF (f?=?150 kHz, H?=?31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected.
Conclusion: Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/CoFe2O4 introduce it as a promising candidate for further clinical studies.
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KEYWORD
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Magnetic nanocomposite (MNC), Breast cancer, Magnetic fluid hyperthermia (MFH), Alternative magnetic field (AMF) and tumor necrosis
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